NME/NM23 nucleoside diphosphate kinase 6

Symbol

NME6 (may also be known as: None)

Organism

Human

Description

Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010]

Orthologs

SymbolSpecies
CELE_R05G6.5 Caenorhabditis elegans
nmdyn-D6 Drosophila melanogaster
nme6 Danio rerio
Nme6 Mus musculus
Nme6 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2861 Gene expression of NME6 decreases with age Molecular adipose tissue Human NME6 —

GO Terms

GO IDGO TermGO Category
GO:0006165 nucleoside diphosphate phosphorylation biological_process
GO:0006183 GTP biosynthetic process biological_process
GO:0006228 UTP biosynthetic process biological_process
GO:0006241 CTP biosynthetic process biological_process
GO:0006915 apoptotic process biological_process
GO:0006916 anti-apoptosis biological_process
GO:0009117 nucleotide metabolic process biological_process
GO:0009142 nucleoside triphosphate biosynthetic process biological_process
GO:0030308 negative regulation of cell growth biological_process
GO:0045839 negative regulation of mitosis biological_process
GO:0005739 mitochondrion cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004550 nucleoside diphosphate kinase activity molecular_function
GO:0005524 ATP binding molecular_function
GO:0016301 kinase activity molecular_function
GO:0016740 transferase activity molecular_function
GO:0046872 metal ion binding molecular_function