RNA binding motif protein 5

Symbol

RBM5 (may also be known as: None)

Organism

Human

Description

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

Orthologs

SymbolSpecies
si:ch73-205c16.2 Danio rerio
Rbm5 Mus musculus
Rbm5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3601 Gene expression of RBM5 increases with age Molecular skin Human RBM5 —

GO Terms

GO IDGO TermGO Category
GO:0000245 spliceosome assembly biological_process
GO:0000381 regulation of alternative nuclear mRNA splicing, via spliceosome biological_process
GO:0000398 nuclear mRNA splicing, via spliceosome biological_process
GO:0006396 RNA processing biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0008380 RNA splicing biological_process
GO:0010467 gene expression biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005681 spliceosomal complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0003676 nucleic acid binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003723 RNA binding molecular_function
GO:0003729 mRNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0046872 metal ion binding molecular_function