dehydrogenase/reductase (SDR family) member 9

Symbol

DHRS9 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Orthologs

SymbolSpecies
dhs-2 Caenorhabditis elegans
Dhrs9 Mus musculus
Dhrs9 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0008209 androgen metabolic process biological_process
GO:0030855 epithelial cell differentiation biological_process
GO:0042448 progesterone metabolic process biological_process
GO:0042572 retinol metabolic process biological_process
GO:0042904 9-cis-retinoic acid biosynthetic process biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004022 alcohol dehydrogenase (NAD) activity molecular_function
GO:0004745 retinol dehydrogenase activity molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0016854 racemase and epimerase activity molecular_function
GO:0047035 testosterone dehydrogenase (NAD+) activity molecular_function