CD163 molecule

Symbol

CD163 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Orthologs

SymbolSpecies
Cd163 Mus musculus
Cd163 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2287 CD163 molecule increases with age Molecular frontal lobe Human CD163 283.0% Increase Gene Expression Level
DAA2288 CD163 molecule increases with age Molecular frontal lobe Human CD163 383.1% Increase Gene Expression Level
DAA2279 CD163 molecule increases with age Molecular parietal lobe Human CD163 488.1% Increase Gene Expression Level
DAA2280 CD163 molecule increases with age Molecular parietal lobe Human CD163 491.5% Increase Gene Expression Level
DAA2272 CD163 molecule increases with age Molecular hippocampus Human CD163 515.7% Increase Gene Expression Level
DAA2273 CD163 molecule increases with age Molecular hippocampus Human CD163 552.3% Increase Gene Expression Level

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1689 CD163 antigen Molecular lung Mouse Cd163 28.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006953 acute-phase response biological_process
GO:0006954 inflammatory response biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0005044 scavenger receptor activity molecular_function
GO:0005515 protein binding molecular_function