Werner syndrome, RecQ helicase-like

Symbol

WRN

Organism

Human

Description

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
wrn-1 Caenorhabditis elegans
wrn Danio rerio
Wrn Mus musculus
Wrn Rattus norvegicus
SGS1 Saccharomyces cerevisiae

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2034 Expression of WRN decreases Molecular blood, immune system Human WRN 52.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000723 telomere maintenance biological_process
GO:0000731 DNA synthesis involved in DNA repair biological_process
GO:0001302 replicative cell aging biological_process
GO:0006139 nucleobase-containing compound metabolic process biological_process
GO:0006200 ATP catabolic process biological_process
GO:0006259 DNA metabolic process biological_process
GO:0006260 DNA replication biological_process
GO:0006284 base-excision repair biological_process
GO:0006310 DNA recombination biological_process
GO:0006974 response to DNA damage stimulus biological_process
GO:0006979 response to oxidative stress biological_process
GO:0007568 aging biological_process
GO:0007569 cell aging biological_process
GO:0009267 cellular response to starvation biological_process
GO:0010225 response to UV-C biological_process
GO:0010259 multicellular organismal aging biological_process
GO:0031297 replication fork processing biological_process
GO:0032066 nucleolus to nucleoplasm transport biological_process
GO:0032508 DNA duplex unwinding biological_process
GO:0040009 regulation of growth rate biological_process
GO:0042981 regulation of apoptotic process biological_process
GO:0044237 cellular metabolic process biological_process
GO:0051345 positive regulation of hydrolase activity biological_process
GO:0005622 intracellular cellular_component
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005730 nucleolus cellular_component
GO:0005813 centrosome cellular_component
GO:0032389 MutLalpha complex cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0000287 magnesium ion binding molecular_function
GO:0000403 Y-form DNA binding molecular_function
GO:0000405 bubble DNA binding molecular_function
GO:0003677 DNA binding molecular_function
GO:0003678 DNA helicase activity molecular_function
GO:0004003 ATP-dependent DNA helicase activity molecular_function
GO:0004386 helicase activity molecular_function
GO:0004527 exonuclease activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0008408 3'-5' exonuclease activity molecular_function
GO:0009378 four-way junction helicase activity molecular_function
GO:0016887 ATPase activity molecular_function
GO:0030145 manganese ion binding molecular_function
GO:0032403 protein complex binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0043138 3'-5' DNA helicase activity molecular_function
GO:0043140 ATP-dependent 3'-5' DNA helicase activity molecular_function
GO:0051880 G-quadruplex DNA binding molecular_function