acid-sensing (proton-gated) ion channel 2

Symbol

ASIC2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Orthologs

SymbolSpecies
asic2 Danio rerio
Asic2 Mus musculus
Asic2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1696 amiloride-sensitive cation channel 1, neuronal (degenerin) Molecular lung Mouse Accn1 57.0% Increase Gene Expression Level