acyl-CoA dehydrogenase, C-4 to C-12 straight chain


ACADM (may also be known as: None)




This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


acdh-7 Caenorhabditis elegans
CG12262 Drosophila melanogaster
acadm Danio rerio
Acadm Mus musculus
Acadm Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001889 liver development biological_process
GO:0005978 glycogen biosynthetic process biological_process
GO:0006082 organic acid metabolic process biological_process
GO:0006111 regulation of gluconeogenesis biological_process
GO:0006635 fatty acid beta-oxidation biological_process
GO:0007507 heart development biological_process
GO:0007584 response to nutrient biological_process
GO:0009409 response to cold biological_process
GO:0009725 response to hormone stimulus biological_process
GO:0009791 post-embryonic development biological_process
GO:0019254 carnitine metabolic process, CoA-linked biological_process
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process
GO:0042493 response to drug biological_process
GO:0042594 response to starvation biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0045329 carnitine biosynthetic process biological_process
GO:0046688 response to copper ion biological_process
GO:0051289 protein homotetramerization biological_process
GO:0051384 response to glucocorticoid stimulus biological_process
GO:0051791 medium-chain fatty acid metabolic process biological_process
GO:0051793 medium-chain fatty acid catabolic process biological_process
GO:0055007 cardiac muscle cell differentiation biological_process
GO:0055114 oxidation-reduction process biological_process
GO:0005739 mitochondrion cellular_component
GO:0005759 mitochondrial matrix cellular_component
GO:0030424 axon cellular_component
GO:0031966 mitochondrial membrane cellular_component
GO:0000062 fatty-acyl-CoA binding molecular_function
GO:0003995 acyl-CoA dehydrogenase activity molecular_function
GO:0016853 isomerase activity molecular_function
GO:0042802 identical protein binding molecular_function
GO:0043958 acryloyl-CoA reductase activity molecular_function
GO:0050660 flavin adenine dinucleotide binding molecular_function
GO:0070991 medium-chain-acyl-CoA dehydrogenase activity molecular_function