anaphase promoting complex subunit 4

Symbol

ANAPC4 (may also be known as: None)

Organism

Human

Description

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
APC4 Drosophila melanogaster
anapc4 Danio rerio
Anapc4 Mus musculus
Anapc4 Rattus norvegicus
cut20 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000090 mitotic anaphase biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0006511 ubiquitin-dependent protein catabolic process biological_process
GO:0007067 mitosis biological_process
GO:0007094 mitotic cell cycle spindle assembly checkpoint biological_process
GO:0016567 protein ubiquitination biological_process
GO:0030071 regulation of mitotic metaphase/anaphase transition biological_process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process
GO:0051301 cell division biological_process
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological_process
GO:0070979 protein K11-linked ubiquitination biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005680 anaphase-promoting complex cellular_component
GO:0005829 cytosol cellular_component
GO:0004842 ubiquitin-protein ligase activity molecular_function
GO:0019903 protein phosphatase binding molecular_function