Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Symbol

FCGR3A

Organism

Human

Description

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006955 immune response biological_process
GO:0050776 regulation of immune response biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009897 external side of plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0019864 IgG binding molecular_function