complement factor D (adipsin)

Symbol

CFD (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
cfd Danio rerio
Cfd Mus musculus
Cfd Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2392 complement factor D preproprotein decreases with age Molecular dermis Human CFD 21.7% Decrease DNA Methylation
DAA2441 complement factor D preproprotein increases with age Molecular mesenchymal stem cell Human CFD 22.2% Increase DNA Methylation

GO Terms

GO IDGO TermGO Category
GO:0002576 platelet degranulation biological_process
GO:0006508 proteolysis biological_process
GO:0006956 complement activation biological_process
GO:0006957 complement activation, alternative pathway biological_process
GO:0007219 Notch signaling pathway biological_process
GO:0007596 blood coagulation biological_process
GO:0030168 platelet activation biological_process
GO:0045087 innate immune response biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0031093 platelet alpha granule lumen cellular_component
GO:0004252 serine-type endopeptidase activity molecular_function
GO:0008233 peptidase activity molecular_function
GO:0008236 serine-type peptidase activity molecular_function