twinfilin actin-binding protein 2
Symbol
TWF2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| twf | Drosophila melanogaster | |
| twf2 | Danio rerio | |
| Twf2 | Mus musculus | |
| LOC684352 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0010592 | positive regulation of lamellipodium assembly | biological_process | |
| GO:0010976 | positive regulation of neuron projection development | biological_process | |
| GO:0030837 | negative regulation of actin filament polymerization | biological_process | |
| GO:0032532 | regulation of microvillus length | biological_process | |
| GO:0032956 | regulation of actin cytoskeleton organization | biological_process | |
| GO:0042989 | sequestering of actin monomers | biological_process | |
| GO:0045773 | positive regulation of axon extension | biological_process | |
| GO:0051016 | barbed-end actin filament capping | biological_process | |
| GO:0071300 | cellular response to retinoic acid | biological_process | |
| GO:0071363 | cellular response to growth factor stimulus | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0030016 | myofibril | cellular_component | |
| GO:0030027 | lamellipodium | cellular_component | |
| GO:0030175 | filopodium | cellular_component | |
| GO:0030426 | growth cone | cellular_component | |
| GO:0032420 | stereocilium | cellular_component | |
| GO:0048471 | perinuclear region of cytoplasm | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0003785 | actin monomer binding | molecular_function | |
| GO:0005080 | protein kinase C binding | molecular_function | |
| GO:0005524 | ATP binding | molecular_function | |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | molecular_function | |