programmed cell death 6

Symbol

PDCD6 (may also be known as: None)

Organism

Human

Description

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Orthologs

SymbolSpecies
CELE_M04F3.4 Caenorhabditis elegans
Alg-2 Drosophila melanogaster
pdcd6 Danio rerio
Pdcd6 Mus musculus
Pdcd6 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0006919 activation of caspase activity biological_process
GO:0008624 induction of apoptosis by extracellular signals biological_process
GO:0051592 response to calcium ion biological_process
GO:0005625 soluble fraction cellular_component
GO:0005634 nucleus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0016020 membrane cellular_component
GO:0031965 nuclear membrane cellular_component
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0046983 protein dimerization activity molecular_function
GO:0048306 calcium-dependent protein binding molecular_function
GO:0060090 binding, bridging molecular_function