DAA1217 |
Brain volume decrease |
Physiological |
brain |
Human |
— |
— |
|
DAA1948 |
Neurogenesis is reduced |
Physiological |
brain |
Mouse |
— |
— |
|
DAA1949 |
Intracellular glutathione content decreases |
Physiological |
brain |
Mouse |
— |
— |
|
DAA1980 |
Reaction time for a visually paced simple motor task increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA1981 |
Selective increase in oxidative damage and decrease in antioxidant function during aging in the substantia nigra |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA1984 |
Layer-specific dendritic regression of pyramidal cells |
Physiological |
prefrontal cortex |
Human |
— |
— |
|
DAA1993 |
Brain volume decreases in a regional-specific way |
Physiological |
brain |
Human |
— |
— |
|
DAA1996 |
Beta-amyloid protein deposition increases |
Physiological |
brain |
Human |
APP |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA2026 |
Mutations in mitochondrial DNA accumulate |
Physiological |
heart, kidney, skeletal muscle, cerebral cortex, cerebellum |
Human |
— |
— |
|
DAA2036 |
Neural stem cell pool declines |
Physiological |
hippocampus |
Mouse |
— |
— |
|
DAA2037 |
Decrease in mitochondrial content and oxidative metabolism in cells |
Physiological |
brain |
Mouse |
— |
— |
|
DAA2041 |
Altered brain mitochondrial metabolism |
Physiological |
brain |
Human |
— |
— |
|
DAA2595 |
Frequency of somatic mitochondrial mutations increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA2596 |
Frequency of mitochondrial DNA deletions increases with age |
Physiological |
brain |
Human |
— |
— |
|
DAA714 |
Neuronal soma shrinks in size |
Physiological |
brain |
Human |
— |
— |
|
DAA717 |
Dendrite regression, reduction in dendrite length |
Physiological |
brain |
Human |
— |
— |
|
DAA718 |
Synaptic density slightly decreases at advanced ages |
Physiological |
frontal lobe |
Human |
— |
— |
|
DAA721 |
Neurofibrillary tangles and Lewy bodies in neurons |
Physiological |
brain |
Human |
— |
— |
|
DAA722 |
Accumulation of neuromelanin in dopaminergic nigral neurons |
Physiological |
substantia nigra |
Human |
— |
— |
|
DAA723 |
Accumulation of extracellular neuritic plaques |
Physiological |
brain |
Human |
— |
— |
|
DAA724 |
Global neuron loss |
Physiological |
cerebral cortex |
Human |
— |
— |
|
DAA725 |
Leukoaraiosis |
Physiological |
white matter |
Human |
— |
— |
|
DAA726 |
Demyelination |
Physiological |
white matter |
Human |
— |
— |
|
DAA727 |
Axon loss |
Physiological |
white matter |
Human |
— |
— |
|