All changes for the tissue integument system (1602)

Identifier Name Type Tissues Organism Gene Data Actions
DAA1000 Decline in epidermis keratinocyte turnover Physiological epidermis Human
DAA1001 Atrophy of hypodermal layer Physiological subcutaneous Human
DAA1002 Decreased ability to modulate heat loss Physiological integument system Human
DAA1003 Wrinkles Physiological skin Human
DAA1004 Decreased/disorganized fibril network of dermis Physiological dermis Human
DAA1005 Loss of smooth padding provided by hypodermal fat cells Physiological skin Human
DAA1006 Decreased amounts of collagen IV and VII, and abnormal elastin in dermis Physiological dermis Human
DAA1009 Dermal collagen atrophies Physiological dermis Human
DAA1011 Changes in glycosaminoglycan/proteoglycan Physiological epidermis, dermis Human
DAA1011 Changes in glycosaminoglycan/proteoglycan Physiological epidermis, dermis Human
DAA1202 arNOX specific activity increases Molecular skin Human ENOX1
DAA1975 Loss of subcutaneous adipose skin layer Physiological skin Mouse
DAA1997 DNA damage increases with age Molecular skin Human
DAA1998 Lipid oxidation increased with age in males Molecular skin Human
DAA1999 PARP activity increases with age in males Molecular skin Human PARP1
DAA2000 NAD(+) levels decrease with age Molecular skin Human
DAA2001 SIRT1 activity negatively correlated with age in males Physiological skin Human SIRT1
DAA2051 Attenuated vasoconstriction response to cold Physiological skin Human
DAA2053 Sweating capacity decreases Physiological sweat gland Human
DAA2383 sperm associated antigen 7 increases with age Molecular dermis Human SPAG7 26.1% Increase DNA Methylation
DAA2384 cyclin-dependent kinase inhibitor 2B isoform 2 increases with age Molecular dermis Human CDKN2B 26.0% Increase DNA Methylation
DAA2385 nerve growth factor; beta polypeptide precursor increases with age Molecular dermis Human NGF 19.3% Increase DNA Methylation
DAA2386 zinc finger protein 549 increases with age Molecular dermis Human ZNF549 16.0% Increase DNA Methylation
DAA2387 selenium binding protein 1 decreases with age Molecular dermis Human SELENBP1 15.7% Decrease DNA Methylation
DAA2388 dehydrogenase/reductase (SDR family) member 3 decreases with age Molecular dermis Human DHRS3 15.8% Decrease DNA Methylation