| DAA925 |
Increase in follicle stimulating hormone (FSH) and luteinizing hormone (LH) preceding menopause |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1200 |
Inhibin levels decline |
Physiological |
plasma |
Human |
— |
Decrease Hormone Level |
|
| DAA916 |
Cortisol levels increased |
Physiological |
plasma |
Human |
— |
— |
|
| DAA698 |
Albumin levels decrease |
Physiological |
plasma |
Human |
— |
— |
|
| DAA921 |
Decrease in melatonin concentration and loss of circadian rhythm for secretion |
Physiological |
plasma, pineal gland |
Human |
— |
— |
|
| DAA1988 |
Decrease in the 24-hour integrated concentration of GH |
Physiological |
plasma |
Human |
GH1 |
— |
|
| DAA1221 |
Morning concentration of sex-hormone binding globulin declines |
Physiological |
plasma |
Human |
— |
— |
|
| DAA910 |
DHEA levels decrease |
Physiological |
plasma |
Human |
— |
— |
|
| DAA2027 |
DNA damage acummulates in hematopoietic stem and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
| DAA1218 |
Morning concentrations of oestradiol decline |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1073 |
Fewer cells and higher apoptosis |
Physiological |
bone marrow |
Human |
— |
— |
|
| DAA909 |
Mean blood glucose level increases |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1180 |
Morning concentrations of testosterone decline |
Physiological |
plasma |
Human |
— |
80.0% Decrease Hormone Level |
|
| DAA1991 |
Hematopoietic cells accumulate random mutations |
Physiological |
hematopoietic stem cells |
Human |
— |
— |
|
| DAA1215 |
Higher adrenocroticotropic hormone levels |
Physiological |
plasma |
Human |
POMC |
— |
|
| DAA2014 |
Microsatellite instability in hematopoietic stem cells and progenitor cells |
Physiological |
hematopoietic stem cells |
Human |
MLH1 |
— |
|
| DAA1181 |
Morning IGF1 decline |
Physiological |
plasma |
Human |
IGF1 |
51.0% Decrease Hormone Level |
|
| DAA2058 |
Mosaic abnormalities increase |
Physiological |
blood, oral cavity |
Human |
— |
— |
|
| DAA699 |
Triglyceride levels increase |
Physiological |
plasma |
Human |
— |
— |
|
| DAA933 |
No changes in erythroid and myeloid progenitor cells evident |
Physiological |
myeloid progenitor cell |
Human |
— |
— |
|
| DAA2013 |
Number and differentiation potential of adipose tissue-derived stem cells declines with age |
Physiological |
mesenchymal stem cell |
Human |
— |
— |
|
| DAA934 |
Number of mature B cells leaving the bone marrow declines |
Physiological |
bone marrow, B cell |
Human |
— |
— |
|
| DAA701 |
Oxidative increase in cystine/cysteine ratio |
Physiological |
plasma |
Human |
— |
— |
|
| DAA1199 |
Serum klotho |
Physiological |
plasma |
Human |
KL |
Increase Hormone Level |
|
| DAA917 |
Plasma and urinary catecholamine elevation after stimuli |
Physiological |
plasma |
Human |
— |
— |
|