PAN2 poly(A) specific ribonuclease subunit
Symbol
PAN2
(may also be known as: None)
Organism
Human
Description
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| F31E3.4 | Caenorhabditis elegans | |
| CG8232 | Drosophila melanogaster | |
| pan2 | Danio rerio | |
| Pan2 | Mus musculus | |
| Pan2 | Rattus norvegicus | |
| PAN2 | Saccharomyces cerevisiae | |
| ubp13 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | biological_process | |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | biological_process | |
| GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening | biological_process | |
| GO:0006511 | ubiquitin-dependent protein catabolic process | biological_process | |
| GO:0010467 | gene expression | biological_process | |
| GO:0016070 | RNA metabolic process | biological_process | |
| GO:0016071 | mRNA metabolic process | biological_process | |
| GO:0005622 | intracellular | cellular_component | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0003676 | nucleic acid binding | molecular_function | |
| GO:0004221 | ubiquitin thiolesterase activity | molecular_function | |
| GO:0004527 | exonuclease activity | molecular_function | |
| GO:0004535 | poly(A)-specific ribonuclease activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |