SET domain, bifurcated 1

Symbol

SETDB1 (may also be known as: None)

Organism

Human

Description

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

Orthologs

SymbolSpecies
set-23 Caenorhabditis elegans
egg Drosophila melanogaster
setdb1b Danio rerio
Setdb1 Mus musculus
Setdb1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3582 Gene expression of SETDB1 increases with age Molecular skin Human SETDB1 —

GO Terms

GO IDGO TermGO Category
GO:0001833 inner cell mass cell proliferation biological_process
GO:0006355 regulation of transcription, DNA-dependent biological_process
GO:0016568 chromatin modification biological_process
GO:0005634 nucleus cellular_component
GO:0005694 chromosome cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005886 plasma membrane cellular_component
GO:0003677 DNA binding molecular_function
GO:0005515 protein binding molecular_function
GO:0008168 methyltransferase activity molecular_function
GO:0008270 zinc ion binding molecular_function
GO:0016740 transferase activity molecular_function
GO:0018024 histone-lysine N-methyltransferase activity molecular_function