centrosomal protein 57kDa


CEP57 (may also be known as: None)




This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]


cep57l1 Danio rerio
Cep57 Mus musculus
Cep57 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2087 centrosomal protein 57kDa increases with age Molecular ovary Human CEP57 86.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0000060 protein import into nucleus, translocation biological_process
GO:0000086 G2/M transition of mitotic cell cycle biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0007286 spermatid development biological_process
GO:0008543 fibroblast growth factor receptor signaling pathway biological_process
GO:0051260 protein homooligomerization biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005813 centrosome cellular_component
GO:0005829 cytosol cellular_component
GO:0005874 microtubule cellular_component
GO:0015630 microtubule cytoskeleton cellular_component
GO:0005515 protein binding molecular_function
GO:0008017 microtubule binding molecular_function
GO:0017134 fibroblast growth factor binding molecular_function
GO:0042803 protein homodimerization activity molecular_function