phospholipase C, eta 2
Symbol
PLCH2
(may also be known as: None)
Organism
Human
Description
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| plch2a | Danio rerio | |
| Plch2 | Mus musculus | |
| Plch2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | biological_process | |
| GO:0008150 | biological_process | biological_process | |
| GO:0016042 | lipid catabolic process | biological_process | |
| GO:0035556 | intracellular signal transduction | biological_process | |
| GO:0046488 | phosphatidylinositol metabolic process | biological_process | |
| GO:0005575 | cellular_component | cellular_component | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0003674 | molecular_function | molecular_function | |
| GO:0004435 | phosphatidylinositol phospholipase C activity | molecular_function | |
| GO:0004871 | signal transducer activity | molecular_function | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |