fasciculation and elongation protein zeta 1 (zygin I)

Symbol

FEZ1 (may also be known as: None)

Organism

Human

Description

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
unc-76 Caenorhabditis elegans
Unc-76 Drosophila melanogaster
fez1 Danio rerio
Fez1 Mus musculus
Fez1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3560 Gene expression of FEZ1 decreases with age Molecular skin Human FEZ1 —

GO Terms

GO IDGO TermGO Category
GO:0006810 transport biological_process
GO:0007155 cell adhesion biological_process
GO:0007399 nervous system development biological_process
GO:0007411 axon guidance biological_process
GO:0010976 positive regulation of neuron projection development biological_process
GO:0045666 positive regulation of neuron differentiation biological_process
GO:0051654 establishment of mitochondrion localization biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005813 centrosome cellular_component
GO:0005874 microtubule cellular_component
GO:0005886 plasma membrane cellular_component
GO:0015630 microtubule cytoskeleton cellular_component
GO:0030424 axon cellular_component
GO:0030425 dendrite cellular_component
GO:0042995 cell projection cellular_component
GO:0005080 protein kinase C binding molecular_function
GO:0005515 protein binding molecular_function
GO:0043015 gamma-tubulin binding molecular_function