gamma-aminobutyric acid (GABA) B receptor, 2

Symbol

GABBR2 (may also be known as: None)

Organism

Human

Description

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

Orthologs

SymbolSpecies
gbb-2 Caenorhabditis elegans
GABA-B-R2 Drosophila melanogaster
gabbr2 Danio rerio
Gabbr2 Mus musculus
Gabbr2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3557 Gene expression of GABBR2 increases with age Molecular skin Human GABBR2 —

GO Terms

GO IDGO TermGO Category
GO:0007186 G-protein coupled receptor signaling pathway biological_process
GO:0007194 negative regulation of adenylate cyclase activity biological_process
GO:0007214 gamma-aminobutyric acid signaling pathway biological_process
GO:0007268 synaptic transmission biological_process
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0043005 neuron projection cellular_component
GO:0045202 synapse cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0004871 signal transducer activity molecular_function
GO:0004872 receptor activity molecular_function
GO:0004965 GABA-B receptor activity molecular_function