chemokine (C-X-C motif) ligand 14

Symbol

CXCL14 (may also be known as: None)

Organism

Human

Description

This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
cxcl14 Danio rerio
Cxcl14 Mus musculus
Cxcl14 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3554 Gene expression of CXCL14 increases with age Molecular skin Human CXCL14 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1681 chemokine (C-X-C motif) ligand 14 Molecular lung Mouse Cxcl14 8.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006935 chemotaxis biological_process
GO:0006955 immune response biological_process
GO:0007165 signal transduction biological_process
GO:0007267 cell-cell signaling biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0008009 chemokine activity molecular_function