neuregulin 2

Symbol

NRG2 (may also be known as: None)

Organism

Human

Description

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

Orthologs

SymbolSpecies
nrg2a Danio rerio
Nrg2 Mus musculus
Nrg2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3553 Gene expression of NRG2 increases with age Molecular skin Human NRG2 —

GO Terms

GO IDGO TermGO Category
GO:0007165 signal transduction biological_process
GO:0009790 embryo development biological_process
GO:0005576 extracellular region cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0005006 epidermal growth factor-activated receptor activity molecular_function
GO:0005102 receptor binding molecular_function
GO:0005154 epidermal growth factor receptor binding molecular_function
GO:0008083 growth factor activity molecular_function
GO:0043125 ErbB-3 class receptor binding molecular_function