polymerase (RNA) I polypeptide C, 30kDa

Symbol

POLR1C (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]

Orthologs

SymbolSpecies
rpac-40 Caenorhabditis elegans
CG3756 Drosophila melanogaster
polr1c Danio rerio
Polr1c Mus musculus
Polr1c Rattus norvegicus
RPC40 Saccharomyces cerevisiae
rpc40 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3551 Gene expression of POLR1C increases with age Molecular skin Human POLR1C —

GO Terms

GO IDGO TermGO Category
GO:0006360 transcription from RNA polymerase I promoter biological_process
GO:0006361 transcription initiation from RNA polymerase I promoter biological_process
GO:0006362 transcription elongation from RNA polymerase I promoter biological_process
GO:0006363 termination of RNA polymerase I transcription biological_process
GO:0006383 transcription from RNA polymerase III promoter biological_process
GO:0006385 transcription elongation from RNA polymerase III promoter biological_process
GO:0006386 termination of RNA polymerase III transcription biological_process
GO:0010467 gene expression biological_process
GO:0005634 nucleus cellular_component
GO:0005654 nucleoplasm cellular_component
GO:0005736 DNA-directed RNA polymerase I complex cellular_component
GO:0003677 DNA binding molecular_function
GO:0003899 DNA-directed RNA polymerase activity molecular_function
GO:0046983 protein dimerization activity molecular_function