polymerase (RNA) I polypeptide C, 30kDa

Symbol

POLR1C (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]

Orthologs

Symbol	Species
rpac-40	Caenorhabditis elegans
CG3756	Drosophila melanogaster
polr1c	Danio rerio
Polr1c	Mus musculus
Polr1c	Rattus norvegicus
RPC40	Saccharomyces cerevisiae
rpc40	Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier	Name	Type	Tissues	Organism	Gene	Data	Actions
DAA3551	Gene expression of POLR1C increases with age	Molecular	skin	Human	POLR1C	—

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GO Terms

GO ID	GO Term	GO Category
GO:0006360	transcription from RNA polymerase I promoter	biological_process
GO:0006361	transcription initiation from RNA polymerase I promoter	biological_process
GO:0006362	transcription elongation from RNA polymerase I promoter	biological_process
GO:0006363	termination of RNA polymerase I transcription	biological_process
GO:0006383	transcription from RNA polymerase III promoter	biological_process
GO:0006385	transcription elongation from RNA polymerase III promoter	biological_process
GO:0006386	termination of RNA polymerase III transcription	biological_process
GO:0010467	gene expression	biological_process
GO:0005634	nucleus	cellular_component
GO:0005654	nucleoplasm	cellular_component
GO:0005736	DNA-directed RNA polymerase I complex	cellular_component
GO:0003677	DNA binding	molecular_function
GO:0003899	DNA-directed RNA polymerase activity	molecular_function
GO:0046983	protein dimerization activity	molecular_function
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