mitogen-activated protein kinase kinase kinase kinase 4

Symbol

MAP4K4 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Map4k4 Mus musculus
Map4k4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2085 mitogen-activated protein kinase kinase kinase kinase 4 increases with age Molecular ovary Human MAP4K4 69.0% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0006468 protein phosphorylation biological_process
GO:0006950 response to stress biological_process
GO:0007243 intracellular protein kinase cascade biological_process
GO:0046328 regulation of JNK cascade biological_process
GO:0005737 cytoplasm cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0004674 protein serine/threonine kinase activity molecular_function
GO:0005083 small GTPase regulator activity molecular_function
GO:0005515 protein binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function