peroxisomal biogenesis factor 16
Symbol
PEX16
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Pex16 | Drosophila melanogaster | |
| pex16 | Danio rerio | |
| Pex16 | Mus musculus | |
| Pex16 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006625 | protein targeting to peroxisome | biological_process | |
| GO:0007031 | peroxisome organization | biological_process | |
| GO:0016557 | peroxisome membrane biogenesis | biological_process | |
| GO:0016558 | protein import into peroxisome matrix | biological_process | |
| GO:0032581 | ER-dependent peroxisome organization | biological_process | |
| GO:0045046 | protein import into peroxisome membrane | biological_process | |
| GO:0005777 | peroxisome | cellular_component | |
| GO:0005778 | peroxisomal membrane | cellular_component | |
| GO:0005779 | integral to peroxisomal membrane | cellular_component | |
| GO:0005783 | endoplasmic reticulum | cellular_component | |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0008022 | protein C-terminus binding | molecular_function | |