CD14 molecule

Symbol

CD14 (may also be known as: None)

Organism

Human

Description

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Orthologs

SymbolSpecies
Cd14 Mus musculus
Cd14 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2204 CD14 molecule increases with age Molecular temporal lobe Human CD14 154.3% Increase Gene Expression Level
DAA2207 CD14 molecule increases with age Molecular hippocampus Human CD14 395.0% Increase Gene Expression Level
DAA2221 CD14 molecule increases with age Molecular parietal lobe Human CD14 186.5% Increase Gene Expression Level
DAA2236 CD14 molecule increases with age Molecular frontal lobe Human CD14 134.9% Increase Gene Expression Level
DAA3038 Gene expression of CD14 decreases with age Molecular skin Human CD14 —

GO Terms

GO IDGO TermGO Category
GO:0006909 phagocytosis biological_process
GO:0006915 apoptotic process biological_process
GO:0006954 inflammatory response biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0008063 Toll signaling pathway biological_process
GO:0009408 response to heat biological_process
GO:0032496 response to lipopolysaccharide biological_process
GO:0032760 positive regulation of tumor necrosis factor production biological_process
GO:0045087 innate immune response biological_process
GO:0050715 positive regulation of cytokine secretion biological_process
GO:0071222 cellular response to lipopolysaccharide biological_process
GO:0071223 cellular response to lipoteichoic acid biological_process
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0031225 anchored to membrane cellular_component
GO:0045121 membrane raft cellular_component
GO:0001530 lipopolysaccharide binding molecular_function
GO:0001847 opsonin receptor activity molecular_function
GO:0016019 peptidoglycan receptor activity molecular_function
GO:0070891 lipoteichoic acid binding molecular_function