glucose 6 phosphatase, catalytic, 3

Symbol

G6PC3 (may also be known as: None)

Organism

Human

Description

This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Multiple transcript variants have been found for this gene, only one of which is expected to express a protein.[provided by RefSeq, Sep 2009]

Orthologs

SymbolSpecies
CG15400-RB Drosophila melanogaster
g6pc3 Danio rerio
G6pc3 Mus musculus
G6pc3 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4258 Gene expression of G6PC3 decreases with age Molecular skin Human G6PC3 —

GO Terms

GO IDGO TermGO Category
GO:0005975 carbohydrate metabolic process biological_process
GO:0006094 gluconeogenesis biological_process
GO:0008645 hexose transport biological_process
GO:0015758 glucose transport biological_process
GO:0015760 glucose-6-phosphate transport biological_process
GO:0016311 dephosphorylation biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0051156 glucose 6-phosphate metabolic process biological_process
GO:0055085 transmembrane transport biological_process
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004346 glucose-6-phosphatase activity molecular_function
GO:0016787 hydrolase activity molecular_function