musculin
Symbol
MSC
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Msc | Mus musculus | |
| Msc | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | biological_process | |
| GO:0006366 | transcription from RNA polymerase II promoter | biological_process | |
| GO:0014707 | branchiomeric skeletal muscle development | biological_process | |
| GO:0060021 | palate development | biological_process | |
| GO:0060539 | diaphragm development | biological_process | |
| GO:0005634 | nucleus | cellular_component | |
| GO:0003677 | DNA binding | molecular_function | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | molecular_function | |
| GO:0003714 | transcription corepressor activity | molecular_function | |