RALBP1 associated Eps domain containing 2

Symbol

REPS2 (may also be known as: None)

Organism

Human

Description

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Reps Drosophila melanogaster
uncharacterized_E7FB Danio rerio
Reps2 Mus musculus
Reps2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3534 Gene expression of REPS2 decreases with age Molecular skin Human REPS2 —

GO Terms

GO IDGO TermGO Category
GO:0006461 protein complex assembly biological_process
GO:0007173 epidermal growth factor receptor signaling pathway biological_process
GO:0005737 cytoplasm cellular_component
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function