pre-mRNA processing factor 3

Symbol

PRPF3 (may also be known as: None)

Organism

Human

Description

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
prp-3 Caenorhabditis elegans
Prp3 Drosophila melanogaster
prpf3 Danio rerio
Prpf3 Mus musculus
Prpf3 Rattus norvegicus
PRP3 Saccharomyces cerevisiae
SPAC29E6.02 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0000375 RNA splicing, via transesterification reactions biological_process
GO:0000398 nuclear mRNA splicing, via spliceosome biological_process
GO:0006397 mRNA processing biological_process
GO:0008380 RNA splicing biological_process
GO:0005634 nucleus cellular_component
GO:0005681 spliceosomal complex cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0015030 Cajal body cellular_component
GO:0016607 nuclear speck cellular_component
GO:0030529 ribonucleoprotein complex cellular_component
GO:0003676 nucleic acid binding molecular_function
GO:0005515 protein binding molecular_function