adaptor-related protein complex 1, sigma 2 subunit

Symbol

AP1S2 (may also be known as: None)

Organism

Human

Description

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Orthologs

SymbolSpecies
ap1s2 Danio rerio
Ap1s2 Mus musculus
Ap1s2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3516 Gene expression of AP1S2 decreases with age Molecular skin Human AP1S2 —

GO Terms

GO IDGO TermGO Category
GO:0006886 intracellular protein transport biological_process
GO:0006892 post-Golgi vesicle-mediated transport biological_process
GO:0006897 endocytosis biological_process
GO:0016032 viral reproduction biological_process
GO:0016044 cellular membrane organization biological_process
GO:0016192 vesicle-mediated transport biological_process
GO:0050690 regulation of defense response to virus by virus biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005765 lysosomal membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005829 cytosol cellular_component
GO:0005905 coated pit cellular_component
GO:0016020 membrane cellular_component
GO:0030117 membrane coat cellular_component
GO:0030119 AP-type membrane coat adaptor complex cellular_component
GO:0030659 cytoplasmic vesicle membrane cellular_component
GO:0031410 cytoplasmic vesicle cellular_component
GO:0008565 protein transporter activity molecular_function