ST3 beta-galactoside alpha-2,3-sialyltransferase 5

Symbol

ST3GAL5 (may also be known as: None)

Organism

Human

Description

Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
st3gal5 Danio rerio
St3gal5 Mus musculus
St3gal5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2852 Gene expression of ST3GAL5 increases with age Molecular adipose tissue Human ST3GAL5 —

GO Terms

GO IDGO TermGO Category
GO:0001574 ganglioside biosynthetic process biological_process
GO:0005975 carbohydrate metabolic process biological_process
GO:0006486 protein glycosylation biological_process
GO:0006688 glycosphingolipid biosynthetic process biological_process
GO:0000139 Golgi membrane cellular_component
GO:0005794 Golgi apparatus cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030173 integral to Golgi membrane cellular_component
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity molecular_function
GO:0008373 sialyltransferase activity molecular_function
GO:0016757 transferase activity, transferring glycosyl groups molecular_function
GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity molecular_function