WNT1 inducible signaling pathway protein 2

Symbol

WISP2 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Wisp2 Mus musculus
Wisp2 Rattus norvegicus

Links to external resources

Changes associated with this gene

GO Terms

GO IDGO TermGO Category
GO:0001558 regulation of cell growth biological_process
GO:0007155 cell adhesion biological_process
GO:0007165 signal transduction biological_process
GO:0007267 cell-cell signaling biological_process
GO:0008285 negative regulation of cell proliferation biological_process
GO:0005576 extracellular region cellular_component
GO:0005625 soluble fraction cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005886 plasma membrane cellular_component
GO:0009986 cell surface cellular_component
GO:0005520 insulin-like growth factor binding molecular_function