cysteine conjugate-beta lyase, cytoplasmic

Symbol

CCBL1 (may also be known as: None)

Organism

Human

Description

This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
nkat-1 Caenorhabditis elegans
ccbl1 Danio rerio
Ccbl1 Mus musculus
Ccbl1 Rattus norvegicus
BNA3 Saccharomyces cerevisiae
SPAC6B12.04c Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3034 Gene expression of CCBL1 increases with age Molecular skin Human CCBL1 —

GO Terms

GO IDGO TermGO Category
GO:0006559 L-phenylalanine catabolic process biological_process
GO:0006569 tryptophan catabolic process biological_process
GO:0006575 cellular modified amino acid metabolic process biological_process
GO:0008652 cellular amino acid biosynthetic process biological_process
GO:0009058 biosynthetic process biological_process
GO:0034641 cellular nitrogen compound metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0070189 kynurenine metabolic process biological_process
GO:0005634 nucleus cellular_component
GO:0005730 nucleolus cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005829 cytosol cellular_component
GO:0008483 transaminase activity molecular_function
GO:0016212 kynurenine-oxoglutarate transaminase activity molecular_function
GO:0016769 transferase activity, transferring nitrogenous groups molecular_function
GO:0016829 lyase activity molecular_function
GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity molecular_function
GO:0030170 pyridoxal phosphate binding molecular_function
GO:0042803 protein homodimerization activity molecular_function
GO:0047312 L-phenylalanine:pyruvate aminotransferase activity molecular_function
GO:0047316 glutamine-phenylpyruvate transaminase activity molecular_function
GO:0047804 cysteine-S-conjugate beta-lyase activity molecular_function
GO:0047945 L-glutamine:pyruvate aminotransferase activity molecular_function