aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Symbol
AKR7A2
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| Akr7a2 | Mus musculus | |
| Akr7a2 | Rattus norvegicus | |
| AAD10 | Saccharomyces cerevisiae |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | biological_process | |
| GO:0006081 | cellular aldehyde metabolic process | biological_process | |
| GO:0016999 | antibiotic metabolic process | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005794 | Golgi apparatus | cellular_component | |
| GO:0004032 | alditol:NADP+ 1-oxidoreductase activity | molecular_function | |
| GO:0009055 | electron carrier activity | molecular_function | |
| GO:0016491 | oxidoreductase activity | molecular_function | |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | molecular_function | |
| GO:0019119 | phenanthrene-9,10-epoxide hydrolase activity | molecular_function | |