slingshot protein phosphatase 2
Symbol
SSH2
(may also be known as: None)
Organism
Human
Description
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Orthologs
| Symbol | Species | |
|---|---|---|
| ssh | Drosophila melanogaster | |
| ssh2b | Danio rerio | |
| Ssh2 | Mus musculus | |
| Ssh2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2938 | Gene expression of SSH2 increases with age | Molecular | adipose tissue | Human | SSH2 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | biological_process | |
| GO:0008064 | regulation of actin polymerization or depolymerization | biological_process | |
| GO:0010591 | regulation of lamellipodium assembly | biological_process | |
| GO:0030036 | actin cytoskeleton organization | biological_process | |
| GO:0050770 | regulation of axonogenesis | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005856 | cytoskeleton | cellular_component | |
| GO:0003779 | actin binding | molecular_function | |
| GO:0004721 | phosphoprotein phosphatase activity | molecular_function | |
| GO:0004725 | protein tyrosine phosphatase activity | molecular_function | |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0016791 | phosphatase activity | molecular_function | |