naked cuticle homolog 2 (Drosophila)
Symbol
NKD2
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Orthologs
| Symbol | Species | |
|---|---|---|
| nkd2 | Danio rerio | |
| Nkd2 | Mus musculus | |
| Nkd2 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006810 | transport | biological_process | |
| GO:0006887 | exocytosis | biological_process | |
| GO:0016055 | Wnt receptor signaling pathway | biological_process | |
| GO:0005737 | cytoplasm | cellular_component | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | cellular_component | |
| GO:0005509 | calcium ion binding | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0031625 | ubiquitin protein ligase binding | molecular_function | |