diacylglycerol O-acyltransferase 2

Symbol

DGAT2 (may also be known as: None)

Organism

Human

Description

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Orthologs

SymbolSpecies
dgat-2 Caenorhabditis elegans
dgat2 Danio rerio
Dgat2 Mus musculus
Dgat2 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4201 Gene expression of DGAT2 decreases with age Molecular skin Human DGAT2 —

GO Terms

GO IDGO TermGO Category
GO:0006071 glycerol metabolic process biological_process
GO:0008610 lipid biosynthetic process biological_process
GO:0019432 triglyceride biosynthetic process biological_process
GO:0019915 lipid storage biological_process
GO:0034383 low-density lipoprotein particle clearance biological_process
GO:0035336 long-chain fatty-acyl-CoA metabolic process biological_process
GO:0035356 cellular triglyceride homeostasis biological_process
GO:0042632 cholesterol homeostasis biological_process
GO:0044255 cellular lipid metabolic process biological_process
GO:0044281 small molecule metabolic process biological_process
GO:0046339 diacylglycerol metabolic process biological_process
GO:0055089 fatty acid homeostasis biological_process
GO:0060613 fat pad development biological_process
GO:0071400 cellular response to oleic acid biological_process
GO:0097006 regulation of plasma lipoprotein particle levels biological_process
GO:0005624 membrane fraction cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005792 microsome cellular_component
GO:0005811 lipid particle cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030176 integral to endoplasmic reticulum membrane cellular_component
GO:0048471 perinuclear region of cytoplasm cellular_component
GO:0003846 2-acylglycerol O-acyltransferase activity molecular_function
GO:0004144 diacylglycerol O-acyltransferase activity molecular_function
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function
GO:0042803 protein homodimerization activity molecular_function