lysyl oxidase-like 4

Symbol

LOXL4 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
lox2 Drosophila melanogaster
loxl4 Danio rerio
Loxl4 Mus musculus
Loxl4 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA4189 Gene expression of LOXL4 decreases with age Molecular skin Human LOXL4 —

Changes associated with the orthologs of this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA1265 lysyl oxidase-like 4 Molecular brain Mouse Loxl4 48.0% Decrease Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0005576 extracellular region cellular_component
GO:0005615 extracellular space cellular_component
GO:0016020 membrane cellular_component
GO:0004720 protein-lysine 6-oxidase activity molecular_function
GO:0005044 scavenger receptor activity molecular_function
GO:0005507 copper ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0016491 oxidoreductase activity molecular_function
GO:0046872 metal ion binding molecular_function