solute carrier family 4, sodium borate transporter, member 11
Symbol
SLC4A11
(may also be known as: None)
Organism
Human
Description
This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Orthologs
| Symbol | Species | |
|---|---|---|
| abts-3 | Caenorhabditis elegans | |
| slc4a11 | Danio rerio | |
| Slc4a11 | Mus musculus | |
| Slc4a11 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006814 | sodium ion transport | biological_process | |
| GO:0006820 | anion transport | biological_process | |
| GO:0009401 | phosphoenolpyruvate-dependent sugar phosphotransferase system | biological_process | |
| GO:0015701 | bicarbonate transport | biological_process | |
| GO:0015992 | proton transport | biological_process | |
| GO:0030003 | cellular cation homeostasis | biological_process | |
| GO:0035445 | borate transmembrane transport | biological_process | |
| GO:0035725 | sodium ion transmembrane transport | biological_process | |
| GO:0042044 | fluid transport | biological_process | |
| GO:0046713 | borate transport | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0016323 | basolateral plasma membrane | cellular_component | |
| GO:0005215 | transporter activity | molecular_function | |
| GO:0005272 | sodium channel activity | molecular_function | |
| GO:0005351 | sugar:hydrogen symporter activity | molecular_function | |
| GO:0005452 | inorganic anion exchanger activity | molecular_function | |
| GO:0015106 | bicarbonate transmembrane transporter activity | molecular_function | |
| GO:0015252 | hydrogen ion channel activity | molecular_function | |
| GO:0015293 | symporter activity | molecular_function | |
| GO:0046715 | borate transmembrane transporter activity | molecular_function | |
| GO:0046983 | protein dimerization activity | molecular_function | |