MAD1 mitotic arrest deficient-like 1 (yeast)

Symbol

MAD1L1 (may also be known as: None)

Organism

Human

Description

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
mdf-1 Caenorhabditis elegans
Mad1 Drosophila melanogaster
mad1l1 Danio rerio
Mad1l1 Mus musculus
Mad1l1 Rattus norvegicus
mad1 Schizosaccharomyces pombe

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3489 Gene expression of MAD1L1 decreases with age Molecular skin Human MAD1L1 —

GO Terms

GO IDGO TermGO Category
GO:0000075 cell cycle checkpoint biological_process
GO:0000087 M phase of mitotic cell cycle biological_process
GO:0000089 mitotic metaphase biological_process
GO:0000090 mitotic anaphase biological_process
GO:0000093 mitotic telophase biological_process
GO:0000236 mitotic prometaphase biological_process
GO:0000278 mitotic cell cycle biological_process
GO:0007093 mitotic cell cycle checkpoint biological_process
GO:0007094 mitotic cell cycle spindle assembly checkpoint biological_process
GO:0051301 cell division biological_process
GO:0000776 kinetochore cellular_component
GO:0000777 condensed chromosome kinetochore cellular_component
GO:0005634 nucleus cellular_component
GO:0005643 nuclear pore cellular_component
GO:0005694 chromosome cellular_component
GO:0005737 cytoplasm cellular_component
GO:0005739 mitochondrion cellular_component
GO:0005813 centrosome cellular_component
GO:0005819 spindle cellular_component
GO:0005829 cytosol cellular_component
GO:0015629 actin cytoskeleton cellular_component
GO:0005515 protein binding molecular_function