calnexin

Symbol

CANX (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
canx Danio rerio
Canx Mus musculus
Canx Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3030 Gene expression of CANX decreases with age Molecular skin Human CANX —

GO Terms

GO IDGO TermGO Category
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I biological_process
GO:0006457 protein folding biological_process
GO:0007568 aging biological_process
GO:0009306 protein secretion biological_process
GO:0018279 protein N-linked glycosylation via asparagine biological_process
GO:0043687 post-translational protein modification biological_process
GO:0044267 cellular protein metabolic process biological_process
GO:0005737 cytoplasm cellular_component
GO:0005783 endoplasmic reticulum cellular_component
GO:0005788 endoplasmic reticulum lumen cellular_component
GO:0005789 endoplasmic reticulum membrane cellular_component
GO:0005791 rough endoplasmic reticulum cellular_component
GO:0005840 ribosome cellular_component
GO:0016020 membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030424 axon cellular_component
GO:0032839 dendrite cytoplasm cellular_component
GO:0042470 melanosome cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0043197 dendritic spine cellular_component
GO:0071556 integral to lumenal side of endoplasmic reticulum membrane cellular_component
GO:0005509 calcium ion binding molecular_function
GO:0005515 protein binding molecular_function
GO:0005529 sugar binding molecular_function
GO:0034185 apolipoprotein binding molecular_function
GO:0035255 ionotropic glutamate receptor binding molecular_function
GO:0051082 unfolded protein binding molecular_function