phosphopantothenoylcysteine synthetase
Symbol
PPCS
(may also be known as: None)
Organism
Human
Description
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| CELE_Y71H2AM.6 | Caenorhabditis elegans | |
| Ppcs | Drosophila melanogaster | |
| ppcs | Danio rerio | |
| Ppcs | Mus musculus | |
| Ppcs | Rattus norvegicus | |
| CAB2 | Saccharomyces cerevisiae | |
| SPCC4B3.18 | Schizosaccharomyces pombe |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2924 | Gene expression of PPCS increases with age | Molecular | adipose tissue | Human | PPCS | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006766 | vitamin metabolic process | biological_process | |
| GO:0006767 | water-soluble vitamin metabolic process | biological_process | |
| GO:0009108 | coenzyme biosynthetic process | biological_process | |
| GO:0015939 | pantothenate metabolic process | biological_process | |
| GO:0044281 | small molecule metabolic process | biological_process | |
| GO:0005829 | cytosol | cellular_component | |
| GO:0004632 | phosphopantothenate--cysteine ligase activity | molecular_function | |
| GO:0016874 | ligase activity | molecular_function | |