phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Symbol
PLA2G7
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Orthologs
| Symbol | Species | |
|---|---|---|
| paf-1 | Caenorhabditis elegans | |
| pla2g7 | Danio rerio | |
| Pla2g7 | Mus musculus | |
| Pla2g7 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0016042 | lipid catabolic process | biological_process | |
| GO:0034374 | low-density lipoprotein particle remodeling | biological_process | |
| GO:0034440 | lipid oxidation | biological_process | |
| GO:0034441 | plasma lipoprotein particle oxidation | biological_process | |
| GO:0050729 | positive regulation of inflammatory response | biological_process | |
| GO:0090026 | positive regulation of monocyte chemotaxis | biological_process | |
| GO:0005576 | extracellular region | cellular_component | |
| GO:0005615 | extracellular space | cellular_component | |
| GO:0034362 | low-density lipoprotein particle | cellular_component | |
| GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity | molecular_function | |
| GO:0005543 | phospholipid binding | molecular_function | |
| GO:0016787 | hydrolase activity | molecular_function | |
| GO:0047499 | calcium-independent phospholipase A2 activity | molecular_function | |