carbonic anhydrase XII
Symbol
CA12
(may also be known as: None)
Organism
Human
Description
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
Orthologs
| Symbol | Species | |
|---|---|---|
| uncharacterized_F1QN | Danio rerio | |
| Ca12 | Mus musculus | |
| Car12 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2786 | Gene expression of CA12 decreases with age | Molecular | adipose tissue | Human | CA12 | — | |
| DAA3022 | Gene expression of CA12 increases with age | Molecular | skin | Human | CA12 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006730 | one-carbon metabolic process | biological_process | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0004089 | carbonate dehydratase activity | molecular_function | |
| GO:0008270 | zinc ion binding | molecular_function | |
| GO:0016829 | lyase activity | molecular_function | |
| GO:0046872 | metal ion binding | molecular_function | |