transient receptor potential cation channel, subfamily V, member 1

Symbol

TRPV1 (may also be known as: None)

Organism

Human

Description

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Orthologs

SymbolSpecies
Trpv1 Mus musculus
Trpv1 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA3458 Gene expression of TRPV1 increases with age Molecular skin Human TRPV1 —

GO Terms

GO IDGO TermGO Category
GO:0001659 temperature homeostasis biological_process
GO:0001660 fever generation biological_process
GO:0001774 microglial cell activation biological_process
GO:0002024 diet induced thermogenesis biological_process
GO:0002790 peptide secretion biological_process
GO:0006629 lipid metabolic process biological_process
GO:0006810 transport biological_process
GO:0006811 ion transport biological_process
GO:0007166 cell surface receptor linked signaling pathway biological_process
GO:0007204 elevation of cytosolic calcium ion concentration biological_process
GO:0007635 chemosensory behavior biological_process
GO:0009268 response to pH biological_process
GO:0009408 response to heat biological_process
GO:0014047 glutamate secretion biological_process
GO:0042637 catagen biological_process
GO:0043065 positive regulation of apoptotic process biological_process
GO:0043434 response to peptide hormone stimulus biological_process
GO:0045429 positive regulation of nitric oxide biosynthetic process biological_process
GO:0048266 behavioral response to pain biological_process
GO:0050954 sensory perception of mechanical stimulus biological_process
GO:0050955 thermoception biological_process
GO:0050968 detection of chemical stimulus involved in sensory perception of pain biological_process
GO:0060083 smooth muscle contraction involved in micturition biological_process
GO:0060454 positive regulation of gastric acid secretion biological_process
GO:0070588 calcium ion transmembrane transport biological_process
GO:0071363 cellular response to growth factor stimulus biological_process
GO:0071502 cellular response to temperature stimulus biological_process
GO:0090212 negative regulation of establishment of blood-brain barrier biological_process
GO:0005829 cytosol cellular_component
GO:0005886 plasma membrane cellular_component
GO:0005887 integral to plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0030054 cell junction cellular_component
GO:0030425 dendrite cellular_component
GO:0032591 dendritic spine membrane cellular_component
GO:0043025 neuronal cell body cellular_component
GO:0045202 synapse cellular_component
GO:0045211 postsynaptic membrane cellular_component
GO:0000166 nucleotide binding molecular_function
GO:0005216 ion channel activity molecular_function
GO:0005262 calcium channel activity molecular_function
GO:0005516 calmodulin binding molecular_function
GO:0005524 ATP binding molecular_function
GO:0017081 chloride channel regulator activity molecular_function