transient receptor potential cation channel, subfamily C, member 1
Symbol
TRPC1
(may also be known as: None)
Organism
Human
Description
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Orthologs
| Symbol | Species | |
|---|---|---|
| trpc1 | Danio rerio | |
| Trpc1 | Mus musculus | |
| Trpc1 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0006811 | ion transport | biological_process | |
| GO:0006816 | calcium ion transport | biological_process | |
| GO:0007411 | axon guidance | biological_process | |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | biological_process | |
| GO:0051480 | cytosolic calcium ion homeostasis | biological_process | |
| GO:0051592 | response to calcium ion | biological_process | |
| GO:0055085 | transmembrane transport | biological_process | |
| GO:0070588 | calcium ion transmembrane transport | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005887 | integral to plasma membrane | cellular_component | |
| GO:0016020 | membrane | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0005216 | ion channel activity | molecular_function | |
| GO:0005262 | calcium channel activity | molecular_function | |
| GO:0005515 | protein binding | molecular_function | |
| GO:0015279 | store-operated calcium channel activity | molecular_function | |
| GO:0044325 | ion channel binding | molecular_function | |
| GO:0070679 | inositol 1,4,5 trisphosphate binding | molecular_function | |