claudin 5
Symbol
CLDN5
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
Orthologs
| Symbol | Species | |
|---|---|---|
| Cldn5 | Mus musculus | |
| Cldn5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
| Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
|---|---|---|---|---|---|---|---|
| DAA2837 | Gene expression of CLDN5 increases with age | Molecular | adipose tissue | Human | CLDN5 | — |
GO Terms
| GO ID | GO Term | GO Category | |
|---|---|---|---|
| GO:0016338 | calcium-independent cell-cell adhesion | biological_process | |
| GO:0005886 | plasma membrane | cellular_component | |
| GO:0005911 | cell-cell junction | cellular_component | |
| GO:0005923 | tight junction | cellular_component | |
| GO:0016021 | integral to membrane | cellular_component | |
| GO:0005198 | structural molecule activity | molecular_function | |
| GO:0042802 | identical protein binding | molecular_function | |