toll-like receptor 5
Symbol
TLR5
(may also be known as: None)
Organism
Human
Description
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Orthologs
Symbol | Species | |
---|---|---|
tlr5b | Danio rerio | |
Tlr5 | Mus musculus | |
Tlr5 | Rattus norvegicus |
Links to external resources
Changes associated with this gene
Identifier | Name | Type | Tissues | Organism | Gene | Data | Actions |
---|---|---|---|---|---|---|---|
DAA2212 | toll-like receptor 5 increases with age | Molecular | hippocampus | Human | TLR5 | 96.4% Increase Gene Expression Level | |
DAA2241 | toll-like receptor 5 increases with age | Molecular | frontal lobe | Human | TLR5 | 48.7% Increase Gene Expression Level | |
DAA2228 | toll-like receptor 5 increases with age | Molecular | parietal lobe | Human | TLR5 | 69.2% Increase Gene Expression Level |
GO Terms
GO ID | GO Term | GO Category | |
---|---|---|---|
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | biological_process | |
GO:0006954 | inflammatory response | biological_process | |
GO:0007165 | signal transduction | biological_process | |
GO:0032757 | positive regulation of interleukin-8 production | biological_process | |
GO:0034123 | positive regulation of toll-like receptor signaling pathway | biological_process | |
GO:0045087 | innate immune response | biological_process | |
GO:0071260 | cellular response to mechanical stimulus | biological_process | |
GO:0005622 | intracellular | cellular_component | |
GO:0005886 | plasma membrane | cellular_component | |
GO:0016021 | integral to membrane | cellular_component | |
GO:0004872 | receptor activity | molecular_function | |
GO:0005149 | interleukin-1 receptor binding | molecular_function | |