toll-like receptor 5

Symbol

TLR5 (may also be known as: None)

Organism

Human

Description

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

Orthologs

SymbolSpecies
tlr5b Danio rerio
Tlr5 Mus musculus
Tlr5 Rattus norvegicus

Links to external resources

Changes associated with this gene

Identifier Name Type Tissues Organism Gene Data Actions
DAA2212 toll-like receptor 5 increases with age Molecular hippocampus Human TLR5 96.4% Increase Gene Expression Level
DAA2241 toll-like receptor 5 increases with age Molecular frontal lobe Human TLR5 48.7% Increase Gene Expression Level
DAA2228 toll-like receptor 5 increases with age Molecular parietal lobe Human TLR5 69.2% Increase Gene Expression Level

GO Terms

GO IDGO TermGO Category
GO:0002755 MyD88-dependent toll-like receptor signaling pathway biological_process
GO:0006954 inflammatory response biological_process
GO:0007165 signal transduction biological_process
GO:0032757 positive regulation of interleukin-8 production biological_process
GO:0034123 positive regulation of toll-like receptor signaling pathway biological_process
GO:0045087 innate immune response biological_process
GO:0071260 cellular response to mechanical stimulus biological_process
GO:0005622 intracellular cellular_component
GO:0005886 plasma membrane cellular_component
GO:0016021 integral to membrane cellular_component
GO:0004872 receptor activity molecular_function
GO:0005149 interleukin-1 receptor binding molecular_function